Submissions from 2015

A comparative analysis of low-dose metronomic cyclophosphamide reveals absent or low-grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens, Giulio Francia

Poly (ADP-ribose) polymerase-1 silences retroviral expression independently of viral DNA integration or global changes in the abundance of cellular heterochromatin, Denisse Gutierrez, Luis Valdes, Che Serguera, Samuel Garcia, and Manuel Llano

Functions of the Hsp90-binding FKBP Immunophilins., Naihsuan Guy, Yenni A. Garcia, Jeffrey C. Sivils, Mario D. Galigniana, and Marc B. Cox

Redundant yet discrete roles of octopamine receptors in female fecundity, Junghwa Lim, Paul Sabandal, Gissel Aranda, Ana Fernandez, John Martin Sabandal, and Kyung-An Han

Label-free Raman imaging to monitor breast tumor signatures, Felicia S. Manciu, K Parra, P Valenzuela, E Sundin, and Giulio Francia

Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity, S. Shrestha, Y. Sun, T. Lufkin, P. Kraus, Y. Or, Y. A. Garcia, N. Guy, P. Ramos, Marc B. Cox, F. Tay, and V. C.L. Lin

Regulation of neurite outgrowth by beta-gamma subunits of G proteins, Jorge A. Sierra-Fonseca, Omar Najera, Jessica Martinez-Jurado, Ellen M. Walker, Armando Varela-Ramirez, Siddhartha Das, Arshad Khan, Manuel Miranda, Nazarius S. Lamango, and Sukla Roychowdhury

Alteration of the MHC class I-restricted self peptide repertoire following viral infection presents peptides containing allelic variation , Charles Spencer, Stephanie B. Conant, Mireya G. Ramos, Chenoa D. Arico, Jennifer J. Gray, Mu Zheng, Xinnan Niu, Andrew J. Link, and Sebastian Joyce

Similarities and distinctions in actions of surface-directed and classic androgen receptor antagonists, J. H. Suh, A. Chattopadhyay, D. H. Sieglaff, C. L. Storer, Marc B. Cox, and P. Webb

In vivo selection of human breast cancer cells that endogenously overexpress Her-2, P Valenzuela, K Parra, S Man, P Xu, W Cruz-Munoz, T Di Desiderio, G Bocci, U Emmenegger, RS Kerbel, and Giulio Francia

Novel dienone curcumin-like analogues display high selective cytotoxicity and pro-apoptotic properties towards aggressive triple-negative breast cancer cells., A. Varela-Ramirez, U Das, N.M. Ortega, E Robles-Escajeda, K Parra, Giulio Francia, J.R. Dimmock, and R.J. Aguilera

HSP90β phosphorylation is a targetable regulator of metastatic transformation, L Xu, R Farmer, S Krishna, A Binkowski, X Huang, R Gordon, M Avram, E Voll, J Pavese, I Ogden, J Chavez, J Bruce, A Mazar, A Nibbs, W Anderson, L Li, B Jovanovic, Giulio Francia, K Scheidt, and R Bergan

Interdisciplinary Research in Climate and Energy Sciences, Xiaofeng Xu, Santonu Goswami, Jay Gulledge, Stan Wullschleger, and Peter Thornton

Redfield-like Stoichiometry of Microbial Biomass in Terrestrial Ecosystems, Xiaofeng Xu and Xia Song

Submissions from 2014


Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs., A C. Alegre-Maller, F C. Mendonça, T A. da Silva, A F. Oliveira, M S. Freitas, E S. Hanna, Igor C. Almeida, N J. Gay, and M C. Roque-Barreira

Lytic anti-alpha-galactosyl antibodies as reliable biomarkers for the follow-up of Chagas disease chemotherapy, Igor C. Almeida


Detection of high levels of anti-α-galactosyl antibodies in sera of patients with Old World cutaneous leishmaniasis: a possible tool for diagnosis and biomarker for cure in an elimination setting., W S. Al-Salem, D M. Ferreira, N A. Dyer, E J. Alyamani, S M. Balghonaim, A Y. Al-Mehna, S Al-Zubiany, Ibrahim el-K, A M. Al Shahrani, H Alkhuailed, M A. Aldahan, A M. Al Jarallh, S S. Abdelhady, M H. Al-Zahrani, Igor C. Almeida, and A Acosta-Serrano

Metronomic Chemotherapy: Pharmacology and Clinical Applications, G Bocci and Giulio Francia

Pharmacokinetics and Pharmacogenetics of Metronomic Chemotherapy, G Bocci and Giulio Francia

Activation of Hindbrain Neurons is Mediated by Portal-Mesenteric Vein Glucosensors During Slow-Onset Hypoglycemia, MaryAnn Bohland, Aleksey V. Matveyenko, Maziyar Saberi, Arshad Khan, Alan G. Watts, and Casey M. Donovan

A dopamine receptor contribute to paraquat-induced neurotoxicity in Drosophila, M. Cassar, A. Issa, T Riemensperger, D Petitgas, T. Rival, H. Coulom, M. Iché-Torres, K.-A. Han, and S. Birman


Historical biogeography of Haloragaceae: An out-of-Australia hypothesis with multiple intercontinental dispersals, Ling-Yun Chen, Shu-Ying Zhao, Kang-Shan Mao, Donald H. Les, Qing-Fang Wang, and Michael Moody


Hyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro., Chuda Chittasupho, Laura J. Shannon, Teruna J. Siahaan, Charlotte M. Vines, and Cory Berkland

Impaired Autophagy Mediates Resistance to Low-Dose Metronomic Cyclophosphamide Chemotherapy, A Chow, Giulio Francia, A Kouri, C Lee, J Ebos, RS Kerbel, and U Emmenegger

Docetaxel plus oral metronomic cyclophosphamide: A phase II study with pharmacodynamic and pharmacogenetic analyses in castration-resistant prostate cancer patients., L Derosa, L Galli, P Orlandi, A Fioravanti, T Di Desiderio, A Fontana, A Antonuzzo, E Biasco, A Farnesi, R Marconcini, Giulio Francia, R Danesi, A Falcone, and G Bocci

NF-κB transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: A role for peptidyl-prolyl isomerase activity, A.G. Erlejman, S.A. De Leo, G.I. Mazaira, A.M. Molinari, M.F. Camisay, Marc B. Cox, G. Piwien-Pilipik, and M.D. Galigniana

Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52, A.G. Erlejman, M. Lagadari, D.C. Harris, Marc B. Cox, and M.D. Galigniana


Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi, F. Gazos-Lopes, M. M. Oliveira, L. V. Hoelz, D. P. Vieira, A. F. Marques, E. S. Nakayasu, M. T. Gomes, N. G. Salloum, P. G. Pascutti, T. Souto-Padron, R. Q. Monteiro, A. H. Lopes, and Igor C. Almeida


Pleistocene Vertebrates of Southwestern USA and Northwestern Mexico, Arthur H. Harris

Selecting the Best Location for a Meteorological Tower: A Case Study of Multi-Objective Constraint Optimization, Aline Jaimes, Craig E. Tweedie, Tanja Magoc, Vladik Y. Kreinovich, and Martine C. Ceberio

Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif, K. Jehle, L. Cato, A. Neeb, C. Muhle-Goll, N. Jung, E. Smith, V. Buzon, L. R. Carbo, E.J. Estebanez-Perpina, K. Schmitz, L. Fruk, B. Luy, Y. Chen, Marc B. Cox, S. Brase, M. Brown, and A.C.B. Cato

Oncogenic Human Papillomaviruses Activate the Tumor-Associated Lens Epithelial-Derived Growth Factor (LEDGF) Gene., Jenny Leitz, Miriam Reuschenbach, Claudia Lohrey, Anja Honegger, Rosita Accardi, Massimo Tommasino, Manuel Llano, Magnus von Knebel Doeberitz, Karin Hoppe-Seyler, and Felix Hoppe-Seyler

Increased Climate Variability Is More Visible Than Global Warming: A General System-Theory Explanation, Octavio Lerma, Craig E. Tweedie, and Vladik Y. Kreinovich


Isoform Specific O-Glycosylation Prediction (ISOGlyP), Version 1.2, Ming-Ying Leung, Gerardo A. Cardenas, Igor C. Almeida, and Thomas A. Gerken


Isoform Specific O-Glycosylation Prediction (ISOGlyP), Version 1.2, Ming-Ying Leung, Gerardo A. Cardenas, Igor C. Almeida, and Thomas A. Gerken


Solution formulation development and efficacy of MJC13 in a preclinical model of castrate-resistant prostate cancer, S. Liang, X. Bian, D.C. Liang, J. Sivils, L. Neckers, Marc B. Cox, and H. Xie

Quantification of a new anti-cancer molecule MJC13 using a rapid, sensitive, and reliable liquid chromatography-tandem mass spectrometry method, S. Liang, X. Bian, J. Sivils, L. M. Neckers, Marc B. Cox, and H. Xie

The octopamine receptor Octβ2R regulates ovulation in Drosophila melanogaster., Junghwa Lim, Paul Sabandal, Ana Fernandez, J. Martin Sabandal, Hyun-Gwan Lee, Peter Evans, and Kyung-An Han

p62/IMP2 promotes breast cancer progression, Y Li, B Peng, N Lei, W Qian, Giulio Francia, and J Zhang


Extracellular vesicles in parasitic diseases, Antonio Marcilla, Lorena Martin-Jaular, Maria Trelis, Armando Menezes-neto, Antonio Osuna, Dolores Bernal, Carmen Fernandez-Becerra, Igor C. Almeida, and Hernando Del Portillo


Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity, V. S. Mariano, A. L. Zorzetto-Fernandes, T. A. da Silva, L. P. Ruas, L. L. Nohara, Igor C. Almeida, and M. C. Roque-Barreira


News & Views: Diversity in the Afterlife, Jennie R. McLaren


Determinants of herbaceous community structure and function in the Kluane region, Jennie R. McLaren, Roy Turkington, and Mark Dale


Co-delivery of autoantigen and B7 pathway modulators suppresses experimental autoimmune encephalomyelitis, Laura Northrup, Joshua Sestak, Bradley Sullivan, Sharadvi Thati, Brittany Hartwell, Teruna Siahaan, Charlotte Vines, and Cory Berkland

The gender of cell lines matters when screening for novel anti-cancer drugs, L. M. Nunes, E. Robles-Escajeda, Y. Santiago-Vazquez, N. M. Ortega, Fresia C. Lema, A. Muro, Gladys Almodovar, U. Das, Siddhartha Das, J. R. Dimmock, Renato Aguilera, and Armando Varela

Mouse Models of Advanced Spontaneous Metastasis for Experimental Therapeutics, K Parra, I Miramontes, Giulio Francia, and RS Kerbel

Evaluation of CTLA-4 Blockage with Metronomic Chemotherapy for the Treatment of Preclinical Breast Cancer , K Parra, C Vidal, P Valenzuela, S Jallad, G Rodriguez, M Felder, N Lerma, G Bocci, U Emmenegger, RA Kirken, and Giulio Francia

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid and progesterone receptors, A. Paul, Y. Garcia, B. Zeirer, C. Patwardhan, O. Gutierrez, Z. Hildenbrand, D. C. Harris, H. A. Balsiger, Jeffrey C. Sivils, J. L. Johnson, J. Buchner, A. Chadli, and Marc B. Cox


Role of the Apt1 protein in polysaccharide secretion by Cryptococcus neoformans., J Rizzo, D L. Oliveira, L S. Joffe, Guoqiang Hu, F Gazos-Lopes, F L. Fonseca, Igor C. Almeida, S Frases, J W. Kronstad, and M L. Rodrigues


Affinity-purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer, A. Rodina, T. Taldone, Y. Kang, P. Patel, J. Koren, P. Yan, E. Gomes, C. Yang, M. Patel, L. Shrestha, S. Ochiana, C. Santarossa, R. Maharaj, A. Gozman, Marc B. Cox, H. Erdjument-Bromage, R. Hendrickson, L Cerchietti, A Melnick, M Guzman, and G Chiosis


Bioavailability and fate of sediment-associated trenbolone and estradiol in aquatic systems, J. L. Sangster, Y. Zhang, R. Hernandez, Y. A. Garcia, J. C. Sivils, Marc B. Cox, D. D. Snow, A. S. Kolok, and S. Bartlet-Hunt

Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity, Yahaira Santiago-Vazquez, S Das, U Das, Elisa Robles-Escajeda, Nora M. Ortega, Fresia C. Lema, Armando Varela, Renato Aguilera, J Balzarini, E De Clercq, S G. Dimmock, D K. Gorecki, and Jonathan J. Dimmock


The Hsp90 ensemble: coordinated Hsp90-cochaperone complexes regulate diverse cellular processes, S. Schwenkert, T. Hugel, and Marc B. Cox


Cloning and Characterization of a Novel Drosophila Stress Induced DNase, Chang-so Seong, Armando Varela, Xiaolei Tang, Brenda Anchondo, Diego Magallanes, and Renato Aguilera


A Synthetic Peptide from Trypanosoma cruzi Mucin-Like Associated Surface Protein as Candidate for a Vaccine against Chagas Disease Article Type:, Carylinda Serna, Joshua A. Lara, Silas P. Rodrigues, Alexandre F. Marques, Igor C. Almeida, and Rosa A. Maldonado

A role for synapsin in FKBP5 modulation of stress responsiveness: convergent evidence from animal and human studies, U. Shmidt, D. Buell, I.A. Ionescu, F. Holsboer, Marc B. Cox, B. Novack, C. Huber, E.B. Binder, M. Schmidt, C. Touma, T. Rein, and L. Hermann

Nerve growth factor induces neurite outgrowth of PC12 cells by promoting G betagamma-microtubule interaction, Jorge Sierra-Fonseca, Omar Najera, Jessica Martinez-Jurado, Ellen Walker, Armando Varela-Ramirez, Arshad M. Khan, Manuel Miranda-Arango, Nazarius S. Lamango, and Sukla Roychowdhury


A novel model for neuroendocrine toxicology: Neurobehavioral effects of BPA exposure in a prosocial species, the prairie vole (Microtus ochrogaster), Alana Sullivan, Elsworth Beach, Luke Stetzik, D'Addezio, Bruce Cushing, and Heather Patisual

Derivation and analysis of preclinical models of human her-2 positive breast cancer, P Valenzuela, S Jallad, K Parra, N Lerma, I Miramontes, A Gallegos, P Xu, W Cruz-Muñoz, S Man, RS Kerbel, and Giulio Francia


Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans., G Vargas, J D. Rocha, D L. Oliveira, P C. Albuquerque, S Frases, S S. Santos, J D. Nosanchuk, A M. Gomes, L C. Medeiros, K Miranda, T J. Sobreira, E S. Nakayasu, Emma Arigi, A Casadevall, A J. Guimaraes, M L. Rodrigues, C G. Freire-de-Lima, Igor C. Almeida, and L Nimrichter

Submissions from 2013

Analysis of Janus Tyrosine Kinase Phosphorylation and Activation

Genome wide mapping of IL-2 induced STAT5 target genes reveals PDE4B as a putative STAT5 regulated gene in human activated PBMCs and lymphoid cancer cells


Granzyme A Produced by g9d2 T Cells Induces Human Macrophages to Inhibit Growth of an Intracellular Pathogen, Getahun Abate, Isaac G. Sakala, Mei Xia, Steven M. Truscott, Christopher S. Eickhoff, Rebecca Linn, Azra Blazevic, Sunil S. Metkar, Guangyong Peng, Christopher J. Froelich, Daniel F. Hoft, and Charles Spencer

FadD17 and FadD19 are acyl-CoA synthetases that initiate cholesterol side-chain degradation in mycobacteria., Johnathan Abou-Fadel, Brian Villalba, Itzel Chavarria, Rhone A. Mendoza, Chenoa Arico, and Hugues Oullete

Human protein disulfide isomerase catalyzes oxidative refolding of anthrax toxin receptor, Naima Alshrif and Jianjun Sun

Conservation status of the world’s reptiles, Monika Böhm, Ben Collen, Jonathan E.M. Baillie, Janice Chanson, Neil Cox, Geoffrey Hammerson, Michael Hoffmann, Suzanne R. Livingstone, Mala Ram, Anders G.J. Rhodin, Simon N. Stuart, Peter Paul van Dijk, Bruce E. Young, Leticia E. Afuang, Aram Aghasyan, Andrés Garcia Aguayo, César Aguilar, Rastko Ajtic, Ferdi Akarsu, Laura R.V. Alencar, Allen Allison, Natalia Ananjeva, Steve Anderson, Claes Andrén, Daniel Ariano-Sánchez, Juan Camilo Arredondo, Mark Auliya, Aziz Avci, Christopher C. Austin, Patrick J. Baker, Andre F. Barreto-Lima, César L. Barrio-Amorós, Dhruvayothi Basu, Michael F. Bates, and Alexandre Batistella

SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter., Murilo Bueno, Jose A. Garcia-Rivera, Jeffrey R. Kugelman, Elisa Morales, German Rosas-Acosta, and Manuel Llano

Neuromodulation of oxidative stress susceptibility by dopaminergic signaling in Drosophila melanogaster, M Cassar, T Riemensperger, H Coulom, M Iché-Torres, S. Birman, and Kyung-An Han

Genetic and mass spectrometric tools for elucidating the physiological function(s) of cytochtrome P450 enzymes from Mycobacterium tuberculosis, Eric D. Chow, Shenheng Guan, Jeffery S. Cox, Alma L. Burlingame, Paul R. Ortiz de Montellano, and Hugues Oullete

Molecular phylogeny of microhylid frogs (Anura: Microhylidae) with emphasis on relationships among New World genera, Rafael O. de Sa, Jeffrey W. Streicher, Relebohile Selenkoyela, Mauricio C. Forlani, Simon P. Loader, Stephen Richards, Celio F. B. Haddad, and Eli Greenbaum


Sculpting MHC class II-restricted self and non-self peptidome by the class I antigen-processing machinery and its consequences on TH cell responses, Srdjan M. Dragovic, Stephanie B. Conant, Jennifer J. Gray, Mu Zheng, Parimal Samir, Xinnan Niu, Magdalini Moutaftsi, Luc Van Kaer, Alessandro Sette, Andrew J. Link, Sebastian Joyce, and Charles Spencer

Microglial Disruption in Young Mice with Early Chronic Exposure to Lead, Mayra G. Flores, Natali Parisi, Tanner Schaub, Miguel Cervantes, and Rodrigo X. Armijos

A comparative analysis of low-dose metronomic cyclophosphamide reveals absent or low-grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens, Giulio Francia

Antiadhesive antibodies targeting e-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro, Giulio Francia

Application of differential display with in situ hybridization verification, to microscopic samples of breast cancer tissue, Giulio Francia

Comparative impact of trastuzumab and cyclophosphamide on her-2 positive human breast cancer xenografts, Giulio Francia

Development of a resistance-like phenotype to sorafenib by human hepatocellular carcinoma cells is reversitble and can be delayed by metronomic chemotherapy, Giulio Francia

Dose-dependent increases in circulating TGF-alpha and other EGFR ligands as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent, Giulio Francia

Downregulation of DNA mismatch repair protein in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents, Giulio Francia

Highly efficacious non-toxic preclinical treatment for advanced metastatic breast cancer using combination oral UFT-cyclophosphamide metronomic chemotherapy, Giulio Francia

Increased plasma vegf as a surrogate marker for optimal therapeutic dosing of vegf-2 monoclonal antibodies, Giulio Francia

In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower dose chemotherapy, Giulio Francia

Long term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-human choriogonadotropin secreting tumor cell lines, Giulio Francia

Low-dose metronomic combined with intermittent bolus-dose cyclophosphamide is an effective long-term chemotherapy treatment strategy, Giulio Francia

Low-dose metronomic cyclophosphamide and weekly tirapazamine: a well tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia, Giulio Francia

Mouse models of advanced spontaneous metastasis for experimental therapeutics, Giulio Francia

Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice, Giulio Francia

Raising the bar for cancer therapy models, Giulio Francia

Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts, Giulio Francia

Tumor-associated fibroblasts as "Trojan Horse" mediators of resistance to anti-vegf therapy, Giulio Francia

Tumors that acquire resistance to metronomic cyclophosphamide chemotherapy retain sensitivity to maximum tolerated dose cyclophosphoamide, Giulio Francia

Vascular edothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receprot-2 levels as a surrogate biomarker for tumor growth, Giulio Francia


Discovering protective T-cell responses by interrogating naturally processed antigenic determinants, Pavlo Gilchuk, Stephanie B. Conant, Hill Timothy, Jennifer J. Gray, Xinann Niu, Mu Zheng, John Erickson, Kelli Boyd, Jennifer McAfee, Carla Oseroff, Sine Hadrup, Jack Bennink, William Hildebrand, Kathryn Edwards, James E. Crowe, John Williams, Soren Buus, Alessandro Sette, Ton N. Schumacher, Andrew J. Link, Sebastian Joyce, and Charles Spencer

Multiple Synaptonemal Complexes (Polycomplexes) in Wild-Type Hermaphroditic Caenorhabditis elegans and their absence in males., Paul Goldstein

Emerald Labyrinth: 21st Century Science and Exploration in the Congo, Eli Greenbaum


Pleistocene Vertebrates of Arizona, New Mexico, and Trans-Pecos Texas, Arthur H. Harris


Isolation, via 454 sequencing, characterization and transferability of microsatellites for Grevillea thelemanniana subsp. thelemanniana and cross-species amplification in the Grevillea thelemanniana complex (Proteaceae), Tanya H. hevroy, Siegfried L. Krauss, Michael G. Gardner, and Michael Moody


New Ruthenium Complexes of Ketoconazole are Active against Leishmania major and Trypanosoma cruzi and Non-toxic to Human and Murine Normal Cells, Eva A. Iniguez, Antonio Sánchez, Alberto Martínez, Miguel A. Vasquez, Aaron Sattler, Roberto A. Sánchez-Delgado, and Rosa A. Maldonado-Medina

Diet Comparison between two syntopic lizards, Aspidiscelis marmorata and Aspidoscelis tesselata (Teiidae) from the northern Chihuahuan Desert of Texas, Jerry D. Johnson, Vicente Mata-Silva, and Aurelio Ramirez-Bautista


Dedications, Amphibian and Reptile Conservation special Mexico Issue, Jerry D. Johnson, Louis W. Porras, Gordon W. Schuett, Vicente Mata-Silva, and Larry D. Wilson