Title
The Cytotoxic Effect of 2-Acylated-1,4-Naphthohydroquinones on Leukemia/Lymphoma Cells.
Publication Date
1-1-2013
Document Type
Article
Abstract
Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line. Several naphthohydroquinones exhibited selective cytotoxic effects on lymphoma/leukemia cells with lowest activity on non-cancer cells. The mode of cell death induced by an acylated naphthohydroquinone, which has a long alkyl chain, was found to be via apoptosis. Furthermore, the naphthohydroquinone provoked mitochondria depolarization and activation of its downstream effector, caspase-3, thus implicating the intrinsic apoptotic pathway as its mechanism to exert cell death.
Comments
Pedroza DA, De Leon F, Varela-Ramirez A, Lema C, Aguilera RJ, Mito S. The cytotoxic effect of 2-acylated-1,4-naphthohydroquinones on leukemia/lymphoma cells. Bioorganic & Medicinal Chemistry 2014 15 January 2014;22(2):842-7.