Effect of platelet rich plasma on marrow stromal cells differentiation seeded on three dimensional scaffolds
Problems such as bone loss due to accidents, congenital and degenerative diseases as well as warfare have increased the need for bone replacement. Currently there are limited treatments, all of which can result in infections, disease transmission and rejection. Tissue engineering, a multidisciplinary science, has been researching a way of substituting and regenerating tissues of all types using cells and porous supports called scaffolds. The advancements have been impressive in some areas such as the fabrication of artificial skin, but applications involving bone regeneration are relatively new and there are still significant advances in research necessary before a clinical product is available. ^ The impressive pluripotent differentiation ability of stromal cells has opened an exciting avenue for research where this precious "raw material" is employed to regenerate diverse cell lines. Platelets are also a rich jewel to be used by the scientific community since studies have shown that these small non-nucleated cells aid in not only wound healing, but also in bone regeneration. Additionally, diverse biomaterials have been tested to improve cell adherence, attachment, growth and communication of cells. The following study not only presents the effect of platelet rich plasma (PRP) on the proliferation and differentiation of rat marrow stromal cells (RMSCs) into osteo-like cells, but also analysis that reveal the importance of the biomaterial chosen to be the support for cell growth.^
Talamas Ugalde, Lucet Vanessa, "Effect of platelet rich plasma on marrow stromal cells differentiation seeded on three dimensional scaffolds" (2008). ETD Collection for University of Texas, El Paso. AAI1453856.