Signal Transducer and Activator of Transcription 5b (Stat5b) Serine 193 Is a Nvel Cytokine-induced Phospho-regulatory Site that is Constitutively activated in Primary Hematopoietic Malignancies

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Background: Stat5 transcription factors regulate genes required for cell growth, survival, and differentiation. Results: A novel cytokine-induced Stat5b phospho-regulatory site was identified and found to be constitutively activated in hematopoietic cancers. Conclusion: This newly defined phosphorylation site acts to regulate Stat5b DNA binding and transcriptional activity. Significance: Therapeutic strategies that disrupt Stat5 serine phosphorylation may be important for controlling hematopoietic diseases such as cancer.

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