Nervios is a culturally defined condition of psychological stress with important implications for Latino health. Using epidemiological research methods, we examined the prevalence of nerviosand associated risk factors, including drug and alcohol use, acculturation, and housing conditions in a population-based study of farm worker families in Mendota, CA (the MICASA Study). A household enumeration procedure was used for sampling, and 843 individuals were interviewed in 2006–2007. In this analysis, we present data on 422 men, 381 accompanied (family) males and 41 unaccompanied males. The prevalence of nervios was 22 %, with no difference in prevalence by household status. Low family incomes, drug use, medium/high acculturation, and poor housing conditions were associated with increased odds of nervios. Self-reported poor/fair health, depressive symptoms, and high perceived stress were also associated with nervios. Since nervioshas been shown to be a clinical indicator of psychiatric vulnerability among Latinos, this analysis furthers public health goals of reducing health disparities.