Date of Award
Doctor of Philosophy
Renato J. Aguilera
The anti-cancer properties of curcumin, the natural yellow pigment in the roots of turmeric (Curcuma longa), have been extensively described over the last century. It has been shown to interfere with multiple cell signaling pathways, including execution of apoptosis, anti-proliferation, anti-angiogenic, and anti-inflammatory properties. However, curcumin's cytotoxic potential is limited when administered in vivo. With the idea of preserving curcumin's characteristics, but improving its bioavailability, analogues have been developed and evaluated in the last decade. Most of the analogues have shown very good anti-cancer activity in various cell lines and one analogue is now in a clinical trial. Nonetheless, this analogue acts through redox-dependent mechanism in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells and causes necrosis in some lymphoid cancerous cells. Thus, the main scope of my research has been the identification and characterization of a lead curcumin analogue, from a library of compounds, as a potent apoptotic agent against leukemia and lymphoma.
Received from ProQuest
Santiago, Yahaira, "Identification And Characterization Of Novel Anti-Leukemia And Anti-Lymphoma Compounds" (2014). Open Access Theses & Dissertations. 1346.